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离子通道调节剂
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rHg1
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rHg1

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Origin: Hadrurus gertschi (Mexican scorpion)

Source description: Recombinant, E.coli.
 
M.W.: 7538.5     Purity: >98%     Effective concentration: 6.2 ± 1.2nM.
 
Sequence: GHHNRVNCLLPPKTGPCKGSFARYYFDIETGSCKAFIYGGCEGNSNNFSEKHHCEKRCRGFRKFGGK.
 
Modifications: Disulfide bonds between Cys8-Cys58, Cys17-Cys41, and Cys33-Cys54.
 
Molecular formula: C329H490N102O92S6.
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Sizes: 50ug, 100ug, 5 x 50ug, 5 x 100ug lyophilized powder.

Activity: Hg1 was a highly selective Kv1.3 channel inhibitor with weak affinity for other potassium channels. Hg1 also function as trypsin inhibitors with dissociation constants of 107 nM.
 
Bioassay: Hg1 inhibited Kv1.3 channel currents with IC50 values of 6.2+1.2 nM.
 
Hg1 is the first characterization of a scorpion Kunitz-type potassium channel toxin family, which contains seven new members and can inhibit both potassium channelsand trypsin. rHg1 at a concentration of 100 nM had a
 
significant inhibitory effect onKv1.3 channels.
References:
 
1. Chen ZY, et al. J Biol Chem. 2012 Apr 20; 287(17):13813-21.
 
2. Schwartz, E.F., et al. (2007) BMC Genomics 8, 119.
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