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rATX II (Neurotoxin ...
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rATX II (Neurotoxin ...

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Origin:Anemonia sulcata, Anemonia viridis (Mediterranean snakelocks sea anemone).

Source description:Recombinant,E.coli.

M.W.:4935    Purity: >98%    Effective concentration: 10-100nM.

Sequence: GVPCLCDSDGPSVRGNTLSGIIWLAGCPSGWHNCKKHGPTIGWCCKQ.

Modifications: Disulfide bonds between Cys4-Cys44, Cys6-Cys34, and Cys27-Cys45.

Molecular formula: C213H324N64O60S6.

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Sizes:50ug, 100ug, 5 x 50ug, 5 x 100ug lyophilized powder.

Activity: ATX II is a potently modulates voltage-gated Na+ channel gating kinetics by delaying its inactivation and prolonging the action potential of excitable membranes. ATX II has been used as a powerful activator of TTX-sensitive and insensitive Na+ channels in various excitable tissue and cell types1-4.

References:

1. Romey, G. et al. (1976) Proc Natl. Acad. USA 73, 4055.

2. Tesseraux, I. et al. (1987) Naunyn Schmiedebergs Arch. Pharmacol. 336, 232.

3. Nishio, M. et al. (1991) Br. J. Pharmacol. 104, 504.

4. Brand, S. et al. (2000) Eur. J. Neurosci. 12, 2387.3. Tripathy, A. et al. (1998) J. Gen. Physiol. 111, 679.

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