Origin:Buthus eupeus (Lesser Asian scorpion).
M.W.:4092 Purity: >98%
Effective concentration:2-10 nM.
Modifications: Disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35.
Molecular formula: C174H267N51O52S6.
Sizes:50ug, 100ug, 5 x 50ug, 5 x 100ug lyophilized powder.
Activity:BeKm-1 inhibits ERG1 K+ channel currents and has minimal effect on ELK1 K+ channels.
BeKm-1 inhibits Kv11.1 (hERG) channels expressed in HEK-293 cells.
hERG channel currents, before and after application of 1nM rBeKm-1. hERG channel currents were elicited by stepping the potential to −50 mVto +50 mV in 10 mV steps (1-s test potentials) from a holding potential of −80 mV for activation.
1. Korolkova, Y.V. et al. (2001) J. Biol. Chem. 276, 9868.
2. Filippov, A.K. et al. (1996) FEBS Lett. 384, 277.