Origin:Mesobuthus Martensii (Buthus martensii).
M.W.:3962 Purity: >98%
Modifications: Disulfide bonds between Cys7-Cys27, Cys13-Cys32, and Cys17-Cys34.
Molecular formula: C169H274N52O47S7.
Sizes:50ug, 100ug, 5 x 50ug, 5 x 100ug lyophilized powder.
Voltage-gated channel (Kv1.3) blocker. rBmKTX blocks Kv1.3 channels with IC50 of 0.0019 nM.
BmKTX inhibits Kv1.3 channels heterologously expressed in HEK-293 cells.
Kv1.3 channel currents, before and after application of 100pM BmKTX. Kv1.3 channel currents were elicited by depolarizing the voltage steps of 200 ms from the holding potential -80 mV to +50 mV.
1. Romi-Lebrun R, et al. Biochemistry. (1997) 36:13473-82.
2.Renisio JG et al. Proteins. (2000) 38:70-8.
3. Dai L et al Biochem J. (2000) 346 Pt 3:805-9.