• 名称: OsK-1 (K+ channel toxin)
  • 编号: MPK-015A MPK-015B MPK-015C
  • 浏览次数: 24
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Origin:Orthochirus scrobiculosus (Central Asian scorpion).

Source description:Recombinant,E.coli.

M.W.:4205     Purity: >98%   Effective concentration: 5-100 nM.

Sequence:GVIINVKCKISRQCLEPCKKAGMRFGKCMNGKCHCTPK.

Modifications: Disulfide bonds between Cys8-Cys28, Cys14-Cys33 and Cys18-Cys35.

Molecular formula: C177H300N56O46S8.

 

Sizes:50ug, 100ug, 5 x 50ug, 5 x 100ug lyophilized powder.

 

Activity:OsK-1 inhibits Kv1.1, Kv1.2, Kv1.3 channels potently and KCa3.1channel moderately2.

 

References:

1. Grishin, E.V. et al. (1996) Pure Appl. Chem. 68, 2105.

2. Mouhat, S. et al. (2005) Biochem. J. 385, 95.

3. Jaravine, V.A. et al. (1997) Biochemistry 36, 1223.