• 名称: rLq2 (K+ channel blocker)
  • 编号: MPK-012A MPK-012B MPK-012C
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Origin:Leiurus quinquestriatus hebraeus (Yellow scorpion).

Source description:Recombinant,E.coli.

M.W.:4353    Purity: >98%    Effective concentration: 5-50nM.

Sequence:QFTQESCTASNQCWSICKRLHNTNRGKCMNKKCRCYS.

Modifications: Disulfide bonds between Cys7-Cys28, Cys13-Cys33 and Cys17-Cys35

Molecular formula: C177H280N60O55S7.

Sizes:50ug, 100ug, 5 x 50ug, 5 x 100ug lyophilized powder.

 

Activity:Lq2 inhibits Kir1.1 K+ inward rectifier channels2, as well as KCa channels1.

 

References:

1. Lucchesi, K. et al. (1989) J. Membr. Biol. 109, 269.

2. Lu, Z. and MacKinnon, R. (1997) Biochemistry 36, 6936.