• 名称: rMaurotoxin (K+ channel blocker, MTX)
  • 编号: MPK-014A MPK-014B MPK-014C
  • 浏览次数: 22
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Origin:Scorpio maurus palmatus (Chactoid scorpion).

Source description:Recombinant,E.coli.

M.W.: 3613   Purity: >98%    

Effective concentration:1-200nM.

Sequence:VSCTGSKDCYAPCRKQTGCPNAKCINKSCK CYGC.

Modifications: Disulfide bonds between Cys3-Cys24, Cys9-Cys29, Cys13-Cys29, and Cys31-Cys34.

Molecular formula: C145H232N46O46S8.

 

Sizes:50ug, 100ug, 5 x 50ug, 5 x 100ug lyophilized powder.

 

Activity:

Maurotoxin activity was extensively assayed on a large array of K+ channels, including KCa (KCa1.1, KCa2.1, KCa2.2, KCa2.2, KCa3.1), KCNA (KCNA1, KCNA2 and KCNA3) and Shaker B K+ currents and seems to be very potent blocker of either KCa3.1 and KCNA2 channels3.

 

References:

1. Kharrat, R. et al. (1996) Eur. J. Biochem. 242, 491.

2. Rodriguez de la Vega, R.C. and Possani, L.D. (2004) Toxicon 43, 865.

3. Kharrat, R. et al. (1997) FEBS. Lett. 406, 284.

4. Carlier, E. et al. (2000) J. Pept. Res. 55, 419.

5. Castle, N.A. et al. (2003) Mol. Pharmacol. 63, 409.

6. Visan, V. et al. (2004) Toxicon. 43, 973.