Origin:Leiurus quinquestriatus hebraeus (Yellow scorpion).
Source description:Recombinant,E.coli.
M.W.:4091 Purity: >98% Effective concentration: 50pM-10nM.
Sequence:GVPINVSCTGSPQCIKPCKDAGMRFGKCMNRKCHCTPK.
Modifications: Disulfide bonds between Cys8-Cys28, Cys14-Cys33, and Cys18-Cys35.
Molecular formula: C169H278N54O48S8.
Sizes:50ug, 100ug, 5 x 50ug, 5 x 100ug lyophilized powder.
Activity:Agitoxin-2 is a blocker of Shaker voltage-gated K+ channels as well as the mammalian homologues of Shaker.
References:
1. Garcia, M.L. et al. (1994) Biochemistry 33, 6834.
2. Cayabyab, F.S. et al. (2000) Eur. J. Neurosci. 12, 1949.
