• 名称: 雷贝毒素(K +通道毒素)
  • 编号: MPK-006
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Origin:Mesobuthus tamulus (Eastern Indian scorpion).

Source description:Recombinant,E.coli.

M.W.:4248      Purity: >98%    

Effective concentration:50-100nM.

Sequence:QFTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ.

Modifications: Disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35.

Molecular formula: C179H277N51O55S7.

 

Sizes:50ug, 100ug, 5 x 50ug, 5 x 100ug lyophilized powder.

 

Activity:Iberiotoxin is a potent selective blocker of the high conductance Ca2+-activated K+ channels (maxi-K).

Bioassay:

Inhibition of BKCa channels heterologously expressed in HEK293 cells by Iberiotoxin.

 

mSlo channel currents, before and during application of 100nM rIberiotoxin. The mSlo currents were activated by a 50 ms voltage step to +100 mV from a prepulse of -180 mV with intracellular 10 μM Ca2+.

 

References:

1. Galvez, A. et al. (1990) J. Biol. Chem. 265, 11083.

2. Koschak, A. et al. (1997) Biochemistry 36, 1943.

3. Meera, P. et al. (2000) Proc. Natl. Acad. Sci. USA. 97, 5562.

4. Meera, P. et al. Proc. Natl. Acad. Sci. USA (2000) 97, 5562