• 名称: rMargatoxin (K+ channel blocker, MgTX)
  • 编号: MPK-013A MPK-013B MPK-013C
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Origin:Centruroides margaritatus (Scorpion).

Source description:Recombinant,E.coli.

M.W.:4179   Purity: >98%    Effective concentration: 50pM-50nM.

Sequence:TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH.

Modifications: Disulfide bonds between Cys7-Cys29, Cys13-Cys34, and Cys17-Cys36.

Molecular formula: C178H286N52O50S7.

Sizes:50ug, 100ug, 5 x 50ug, 5 x 100ug lyophilized powder.

 

Activity:Margatoxin is a potent selective inhibitor of voltage-dependent potassium channels such as Kv1.3

 

References:

1. Leonard, R.J. et al. (1992) Proc. Natl. Acad. Sci. USA 89, 10094.

2. Garcia-Calvo, M. et al. (1993) J. Biol. Chem. 268, 18866.