• 名称: rKaliotoxin-1 (K+ channel blocker, KTX-1)
  • 编号: MPK-011
  • 浏览次数: 67
  • 已销售数量:0件

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Origin:Androctonus mauretanicus mauretanicus (Scorpion).

Source description:Recombinant,E.coli.

M.W.:4022        Purity: >98%    

Effective concentration:10-100nM.

Sequence:GVEINVKCSGSPQCLKPCKDAGMRFGKCMNRKCHCTP.

Modifications: Disulfide bonds between Cys8-Cys28, Cys14-Cys33, and Cys18-Cys35.

Molecular formula: C165H277N53O48S8.

 

Sizes:50ug, 100ug, 5 x 50ug, 5 x 100ug lyophilized powder.

 

Activity:Kaliotoxin-1 is a potent inhibitor of large conductance Ca2+- activated K+ channels (BKCa). Kaliotoxin-1 also binds the dendrotoxin sensitive voltage-dependent K+ channel.

 

References:

1. Crest, M. et al. (1992) J. Biol. Chem. 267, 1640.

2. Rodriguez de la Vega, R.C. and Possani, L.D. (2004), Toxicon 43, 865.

3. Mourre, C. et al. (1999) J. Pharmacol. Exp .Ther. 291, 943.

4. Grissmer, S. et al. (1994) Mol. Pharmacol. 45, 1227.

5. Hopkins, W.F. et al. (1996) Curr. Pharmaceut. Design. 2, 389.