• 名称: rTertiapin (TPN)
  • 编号: MPK-017A MPK-017B MPK-017C
  • 浏览次数: 25
  • 已销售数量:0件

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Origin:Apis mellifera (Honeybee).

Source description:Recombinant,E.coli.

M.W.:2456   Purity: >98%    Effective concentration: 10-100nM.

Sequence:ALCNCNRIIIPHMCWKKCGKK.

Modifications: Disulfide bonds between Cys3-Cys14, and Cys5-Cys18.

Molecular formula: C106H175N33O23S5.

Sizes:50ug, 100ug, 5 x 50ug, 5 x 100ug lyophilized powder.

 

Activity:Tertiapin blocks a range of inward rectifier K+ channels (Kir) in particular ROMK1 and GIRK but with no effect on Kir2 family members1. In addition, it was shown to inhibit acetylcholine induced K+ currents in heart2,3.

 

References:

1. Jin, W. and Lu, Z. (1998) Biochemistry 37, 13291.

2. Drici, M.D. et al. (2000) ) Br. J. Pharmacol. 131, 569.

3. Kitamura, H. et al. (2000) J. Pharmacol. Exp. Therap. 293, 196.