Aprotinin

  • Advanced Fermentation Platforms
  • Both Prokaryotic&Eukaryotic System
  • GMP Standard Aprotinin Production
Inquiry Now
Premium Protease

Recombinant Aprotinin

Aprotinin (Iniprol) is a competitive and reversible serine protease inhibitor, it can bind with serine proteases to form stable complexes and block the active sites of these enzymes. As this reversible binding, most aprotinin-protease complexes dissociate under extreme pH conditions (pH<3.0, or pH>10.0). Aprotinin can inhibit chymotrypsin, trypsin, plasmin, and kallikrein, but cannot inhibit Factor Xa, thrombin, pepsin, papain, and carboxypeptidases A and B.

Morebio recombinant Aprotinin is produced in E.coli under GMP regulations. Our aprotinin is free from animal-derived components, which eliminates the risk of contamination with animal-derived viruses.

Aprotinin
Premium Protease

Aprotinin Specification

  • Protease Name: Recombinant Aprotinin
  • CAS Number: 9087-70-1
  • Alternative Name: Antagosan; Anikrein; Antilysin(e); Basic pancreatic trypsin inhibitor; BPTI; Bayer A 128; Kallikrein-trypsin inactivator; Fosten; Iniprol; Kunitz protease inhibitor; Onquinin; Repulson; RP-9921; Ryker 52G; Trasylol; Triazinin; Zymofren
  • Grade: Bioactive, Carrier Free, GMP
  • Nature: Recombinant
  • Host Species:  E.coli
  • Source:  E.coli recombinant expression
  • Purity:  ≥95% (SDS-PAGE gel and HPLC analyses)
  • Endotoxin:  <1.0 EU per μg
  • Form:  Lyophilized powder
  • Appearance:  White, off-withe powder
  • Molecular Weight: 6511g/mol
  • Production Method: GMP Production
Trypsin Reference

Structure

Aprotinin is consisting of 58 amino acids with three cross-linked disulfide bonds, it is a monomeric globular protein derived from bovine lung. Recombinant Aprotinin has the same amino acid sequence as bovine lung-derived Aprotinin, and exhibits the same enzymatic properties. It is applied as a substitute for animal-derived Aprotinin in various biotechnological processes, like: activity inhibition of serine protease in protein production and cell culture.

Application

  • Cell culture application
  • Protein purification
  • Diagnostic testing
  • Pharmaceutical design
Aprotinin
Production Service

Aprotinin Production

Morebio develops our unique expression system of E.coli or Pichia pastoris for recombinant secretory proteins. We are the premier company to provide a professional and comprehensive microbial expression platform. We have years of experience with specific bioproducts in different microbial systems.

Custom Protein Expression

  • Large-scale production as requested
  • Tag removal as requested
  • Post-transitional modifications
  • Downstream purification system
  • Fast turn-around time
Custom Protein Expression

Gene Expression Workflow

  • Genes Optimization&Synthesis
  • Plasmid Construction
  • Transform & Induce
  • Protein Purification and Characterization
  • Post Processing
Gene Expression

Fermentation Capability

  • Identify and optimize the suitable expression system
  • Fermentation platform with large fermentation taks, bioreactors, large-scale purification systems
  • Genetic level for target enzymes production
  • High-purity and kilogram level products
Fermentation Capability

GMP Fermentation

  • GMP cell line banking with dedicated facilities
  • GMP manufacturing from pre-clinical to commercial scale
  • Validated GMP computer system
  • Advanced quality management systems
GMP Fermentation