Kallikrein-1

  • Advanced Fermentation Platforms
  • Both Prokaryotic&Eukaryotic System
  • GMP-Compliant Pharmaceutical Purity
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KLK1 Protease

Kallikrein-1(KLK1, tissue kallidrein) is a member of the peptidase S1 family, it is a serine protease enzyme. KLK1 can cleave kininogen to release the vasoactive kinin peptide (bradykinin or lysyl-bradykinin), which can regulate vasodilation, reduce blood pressure, smooth muscle relaxation and contraction, respond to inflammation, and tissue injury.

KLK1 has a beneficial role in protecting against tissue damage by its anti-inflammatory and antioxidant actions. It is also investigated as a potential biomarker for kidney injury and various cancers.

Kallikrein-1
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Kallikrein-1 Specification

  • Protease Name: Kallikrein-1
  • CAS Number: 9001-01-8
  • Alternative Name: KLK1, Tissue Kallikrein, Kallikrein-1, EC 3.4.21.35, Kallikrein Serine Protease 1, Glandular Kallikrein 1
  • Grade: Bioactive, Carrier Free, GMP
  • Nature: Recombinant
  • Host Species:  E.coli
  • Source:  E.coli recombinant expression
  • Purity:  ≥95% (SDS-PAGE gel and HPLC analyses)
  • Endotoxin:  <1.0 EU per μg
  • Form:  Lyophilized powder
  • Appearance:  White, off-withe powder
  • Molecular Weight: 32 kDa
  • Production Method: GMP Production
Kallikrein-1 Reference

Features

  • High Specificity: specific recognizance and cleavage of Met-Lys and Arg-Ser bonds in kininogen
  • High Purity: ≥95%
  • Animal Free: Recombinant production, free of exogenous viral contamination, no animal-derived materials

Application

  • Biomarker in Cancer research
  • Drug application in hypertension and occlusion
Kallikrein-1
Production Service

Kallikrein-1 Production

Morebio develops our unique expression system of E.coli for recombinant secretory proteins. We are the premier company to provide a professional and comprehensive microbial expression platform. We have years of experience with specific bioproducts in different microbial systems.

Custom Protein Expression

  • Large-scale production as requested
  • Tag removal as requested
  • Post-transitional modifications
  • Downstream purification system
  • Fast turn-around time
Custom Protein Expression

Gene Expression Workflow

  • Genes Optimization&Synthesis
  • Plasmid Construction
  • Transform & Induce
  • Protein Purification and Characterization
  • Post Processing
Gene Expression

Fermentation Capability

  • Identify and optimize the suitable expression system
  • Fermentation platform with large fermentation taks, bioreactors, large-scale purification systems
  • Genetic level for target enzymes production
  • High-purity and kilogram level products
Fermentation Capability

GMP Fermentation

  • GMP cell line banking with dedicated facilities
  • GMP manufacturing from pre-clinical to commercial scale
  • Validated GMP computer system
  • Advanced quality management systems
GMP Fermentation