Mazdutide

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  • US DMF Certificate
  • GMP-Compliant Pharmaceutical Purity
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Mazdutide API

Mazdutide is a dual agonist of the glucagon receptor and GLP-1 receptor, it is an analog of oxyntomodulin (OXM3). Once-weekly Mazdutide led to clinically relevant reductions in body weight of adults with overweight or obesity in China.

Mazdutide
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Mazdutide

  • Peptide Name: Mazdutide
  • CAS Number: 2259884-03-0
  • Formula: C207H317N45O65
  • Molecular Weight: 4476g/mol
  • Sequence: H-{Aib}-QGT FTSDY SKYLD EKKAK EFVEW LLEGG PSSG
  • Purity: 98%
  • Type: Drug Peptides, Synthetic peptide,
    GLP-1 receptor agonist, Glucagon receptor agonist
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Mazdutide Description

Mazdutide is developed for adult weight management with obesity or overweight and treatment of type 2 diabetes(T2D). In 2025, Mazdutide is approval for application in long-term weight management of adults in China. It is applied in combination with diet control and physical activities. Additionally, Mazdutide is under clinical evaluation for treatment of metabolic dysfunction-associated fatty liver disease, obstructive sleep apnoea, and alcohol use disorder.

Compared to Dulaglutide, clinic research shows that Mazdutide provides superior reduction in HbA1 and body weight of participants with T2D. It is general safe with higher incidence of gastrointestinal adverse events than Dulaglutide.

Mazdutide-2000
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Mazdutide Reference

Mazdutide Mechanism

  • Mazdutide is a dual dual glucagon-like peptide 1 receptor agonist (GLP-1RA) and glucagon receptor agonist, it is the first peptide in its class. It regulates appetite, metabolism, and glucose control by activation of both GLP-1 and glucagon receptors.
  • GLP-1 receptor agonists(GLP-1 RAs) are applied widely in treatment of type 2 diabetes, these receptor agonists stimulate insulin synthesis and secretion in a glucose-dependent manner and result in weight loss.
  • Glucagon receptor agonists can increase the glucose production of the liver, but not a good therapeutic option. Once combined, GCG RAs with GLP-1 RAs are effective in reducing fat mass and improving glucose tolerance.
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Quality Insurance

  • Morebio has the stringent control standards in the manufacturing process
  • Available in bulk quantities for global demands
  • Adheres to US FDA, EMA, GMP guidelines

Administration

  • Mazdutide is administered by pre-fill auto-injector subcutaneously(under the skin) in the stomach area, once a week.
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