Mesenchymal Stem Cell

  • Self-developed Cell Culture Platform
  • Both 2D and 3D Manufacturing Technology
  • GMP Standard MSC Production
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MSC

Mesenchymal stem cells (MSCs) are also referred to as mesenchymal stromal cells, multipotent signaling cells, and mesenchymal progenitor cells. MSCs are multipotent stromal cells that can differentiate into various cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells), and adipocytes (fat cells, which give rise to marrow adipose tissue).

The primary function of MSCs is secreting and recruiting different biological factors, responding to injuries and infections, and modulating inflammatory processes to facilitate tissue repair and regeneration.

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Final Function

Differentiation Capacity

MSCs have great self-renewal capacity with multipotency, β-catenin is a central molecule in maintaining the stemness via regulation of EZH2. the standard multipotency is differentiation of cells into osteoblasts, adipocytes and chondrocytes as well as myocytes.

Immunomodulatory Effects

MSCs have effects on innate and specific immune cell, and suppress tumor growth. They can produce different immunomodulatory molecules, including: prostaglandin E2 (PGE2), nitric oxide, indoleamine 2,3-dioxygenase (IDO), interleukin 6 (IL-6), and other surface markers.

Mesenchymal Stem Cells
Antimicrobial

Antimicrobial Properties

MSCs can affect macrophages, neutrophils, NK cells, mast cells, and dendritic cells in innate immunity.

  • MSCs migrate to injury sites with anti-inflammatory effect through PGE2 macrophages polarization
  • PGE2 can inhibit mast cells and degranulate TNF-α production.
  • PEGE2 and IDO can inhibit proliferation and cytotoxic activity of NK cells.
  • MSCs can reduce expression of NK cell receptors: NKG2D, NKp44, NKp30.
  • MSCs inhibit respiratory flare and apoptosis of neutrophils by cytokines IL-6 and IL-8.
  • IL-6 and PGE2 of MSCs can inhibit differentiation and expression of dendritic cell surface markers.
Cell Application

Clinical Applications

MSCs are applied in different clinical investigation for diseases treatment, particularly in autoimmune diseases, graft versus host disease, Crohn’s disease, multiple sclerosis, systemic lupus erythematosus and systemic sclerosis.

MSCs can produce several antimicrobial peptide(AMPs), such as human cathelicidin LL-37,[46] β-defensins,[47] lipocalin 2[48] and hepcidin. All these peptides and IDO are responsible for the broad-spectrum antibacterial activity of MSCs.

The MSCs can produce a large number of soluble or vesicle-bound growth factors ,cytokines, mRNAs.

MSCs