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离子通道调节剂
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rScyllatoxin (K+ cha...
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rScyllatoxin (K+ cha...

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Origin:Leiurus quinquestriatus hebraeus (Yellow scorpion).

Source description:Recombinant,E.coli.

M.W.:3424        Purity:>98%    

Effective concentration:20-200 nM.

Sequence:AFCNLRMCQLSCRSLGLLGKCIGDKCECVKH.

Modifications: Disulfide bonds between Cys3-Cys21, Cys8-Cys26, and Cys12-Cys28.

Molecular formula: C142H237N45O39S7.

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Sizes:50ug, 100ug, 5 x 50ug, 5 x 100ug lyophilized powder.

Activity:Scyllatoxin inhibits small conductance Ca2+-activated K+ channels (SK)1-3.

Bioassay:

Scyllatoxin inhibits SKCa3 channels heterologously expressed in HEK-293 cells.

 

SKCa3 channel currents, before and after application of 100nM rScyllatoxin. The SKCa currents were elicited by 1µM internal calcium and 200 ms voltage ramps from -140 to +40 mV at the holding potential of 0 mV.

References:

1. Wadsworth, J.D. et al. (1994) J. Biol. Chem. 269, 18053.

2. Grissmer, S. et al. (1992) J. Gen. Physiol. 99, 63.

3. Jager, H. and Grissmer, S. (1997) Cell. Physiol. Biochem. 7, 179.

4. Chicchi, G.G. et al. (1988) J. Biol. Chem. 263, 10192.

5. Rodriguez de la Vega, R.C. and Possani, L.D. (2004) Toxicon 43, 865.

6. Auguste, P. et al. (1992) Biochemistry 31, 648.

7. Auguste, P. et al. (1990) J. Biol. Chem., 265, 4753.

8. Goh, J.W. et al. (1992) Brain Res. 591. 165.

9. Pedarzani, P. et al. (2000) J. Physiol. 527, 283.

10. Strobaek, D. et al. (2000) Br. J. Pharmacol. 129, 991.

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