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rADWX-1

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  Origin:Mesobuthus Martensii (Buthus martensii).

Source description:Recombinant,E.coli.

M.W.: 4072     Purity: >98%    

Effective concentration:0.0019-0.65nM.

Sequence:VGINVKCKHSRQCLKPCKDAGMRFGKCTNGKCHCTPK.

Modifications: Disulfide bonds between Cys7-Cys27, Cys13-Cys32, and Cys17-Cys34.

Molecular formula: C169H281N57O46S7.

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Sizes: 50ug, 100ug, 5 x 50ug, 5 x 100ug lyophilized powder.

Activity:Voltage-gated channel (Kv1.3 and Kv1.1) blocker. ADWX-1 blocks Kv1.3 channels with IC50 of 0.0019 nM, and inhibits Kv1.1 channels with IC50 of 0.65nM.

Bioassay:

ADWX-1 inhibits Kv1.3 channels heterologously expressed in HEK-293 cells.

Kv1.3 channel currentsbefore and after application of 10pM ADWX-1. Kv1.3 channel currents were elicited by depolarizing the voltage steps of 200 ms from the holding potential -80 mV to +50 mV.

References:

1. Han S et al. J Biol Chem. (2008) 283:19058-65.

2. Yin SJ et al. (2008) 7:4890-7.

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