Origin:Mesobuthus Martensii (Buthus martensii).
M.W.: 4072 Purity: >98%
Modifications: Disulfide bonds between Cys7-Cys27, Cys13-Cys32, and Cys17-Cys34.
Molecular formula: C169H281N57O46S7.
Sizes: 50ug, 100ug, 5 x 50ug, 5 x 100ug lyophilized powder.
Activity:Voltage-gated channel (Kv1.3 and Kv1.1) blocker. ADWX-1 blocks Kv1.3 channels with IC50 of 0.0019 nM, and inhibits Kv1.1 channels with IC50 of 0.65nM.
ADWX-1 inhibits Kv1.3 channels heterologously expressed in HEK-293 cells.
Kv1.3 channel currents，before and after application of 10pM ADWX-1. Kv1.3 channel currents were elicited by depolarizing the voltage steps of 200 ms from the holding potential -80 mV to +50 mV.
1. Han S et al. J Biol Chem. (2008) 283:19058-65.
2. Yin SJ et al. (2008) 7:4890-7.